The Vaccine and Immunotherapy Center VIC at Massachusetts General Hospital seeks to improve human health by accelerating the development of new broadly applicable, safe and cost effective vaccines and immune-based therapeutics.
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We focus on enhancing the speed and effectiveness by which these drugs and vaccines are advanced from laboratory discovery to clinical development, on promoting an understanding of the need for accelerated development of new medical treatments, and on training the next generation of scientists to continue this important work. VIC prioritizes for development innovations with the potential for making a broad impact on cancer, infectious diseases, type 1 diabetes and other immune-mediated diseases, as well as the promise of benefitting patients across the globe.
We actively manage the development of these candidates, drawing on the expertise and experience of medical and business professionals who collectively understand each aspect of the development path from discovery to the use of new medicines in people. Through the support of public grants and private philanthropy, VIC has supported rapid-pace, high-impact research initiatives that are in the process of safely transitioning from the research lab to patients. I was diagnosed with type 1 diabetes T1D when I was 9 years old. One day I was a considered a healthy child and the next I was I learning The event took place in the elegant This lecture series, Therapeutic cancer vaccines; past, present and future.
Chiang, C. Whole tumor antigen vaccines: where are we?
The Koch Institute: Summer Symposium
Vaccines 3 , — Srivatsan, S. Allogeneic tumor cell vaccines: the promise and limitations in clinical trials. Mullard, A. The cancer vaccine resurgence.
Drug Discov. Butterfield, L. Dendritic cells in cancer immunotherapy clinical trials: are we making progress?
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- A primer on recent developments in cancer immunotherapy, with a focus on neoantigen vaccines.
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Song, W. Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap. Wong, C. Multistage nanoparticle delivery system for deep penetration into tumor tissue. Sahay, G. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling.
Immunotherapy for cancer: synthetic carbohydrate-based vaccines
Bioreducible polymeric nanoparticles containing multiplexed cancer stem cell-regulating miRNAs inhibit glioblastoma growth and prolong survival. Nano Lett. Engel, A. The pharmacokinectics of toll-like receptor agonists and the impact on the immune system. Expert Rev. Whiteside, T. Emerging opportunities and challenges in cancer immunotherapy.
Lyon, J. Engineering challenges for brain tumor immunotherapy. Sagiv-Barfi, I. Eradication of spontaneous malignancy by local immunotherapy. Hu, B.optinboost.com/pav-top-smartphone-location.php
The future of cancer treatment is based on a medical miracle: cancers that melt away on their own
Cell Rep. Matsumura, Y.
New concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Gerlowski, L. Microvascular permeability of normal and neoplastic tissues. Xu, X. Cancer nanomedicine: from targeted delivery to combination therapy. Trends Mol. Bertrand, N. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Mitchell, M.
Engineering and physical sciences in oncology: challenges and opportunities. Cancer 17 , — Wilhelm, S. Analysis of nanoparticle delivery to tumors.
Seeing Is Believing: Therapeutic Cancer Vaccines
Ramanathan, R. Correlation between ferumoxytol uptake in tumor lesions by MRI and response to nanoliposomal irinotecan in patients with advanced solid tumors: a pilot study. Lee, H. Mishra, P. PEGylation in anti-cancer therapy: an overview. Asian J.